Ph.D Postdoctoral research post Systems Biology

at University of Bristol in United Kingdom

The position is for 2 years to work in the Gough group at the University of
Bristol, ranked 32nd in the world according to the QS Top Universities
ranking. Although placed in the Computer Science department, the position
will involve interacting mostly with the Gough group but also with
collaborators at the MRC Laboratory for Molecular Biology in Cambridge, and
around the world.
The position will include working with data from the SUPERFAMILY database.
The initial project is flexible, depending on the candidate, but it must
contribute to development of the SUPERFAMILY database and exploit the
resource to answer biological questions. We expect this to lead to
publications in high profile journals. Many projects in the group relate to
evolution, e.g. [Chothia, C. and Gough, J. (2009) Genomic and Structural
Aspects of Protein Evolution. Biochem. J. 419(1), 15-28.]. Two areas of
potential development also include: inclusion of functional information, and
automation of the pipeline integrating with SCOP and ASTRAL. The functional
work includes automatically adding Gene Ontology but also targetting
specific biological processes such as calcium signalling and transcription
factors for deeper investigation from a functional and an evolutionary
perspective. A candidate may also bring their own research interests to the

All applicants must possess a PhD, preferrably in: bioinformatics, systems
biology, molecular biology or some related subject. Computer skills are
essential, in particular bioinformatics and data
analysis/manipulation/management skills, e.g. PERL, SQL and Linux. Previous
experience of protein sequence analysis is a plus, but not essential. What
is important is an interest in molecular biology and some previous
experience working with biological data. We kindly ask that applicants
explain in their cover letter what interests them about this position, and
how their skills and expertise can contribute. We invite applicants both
from computational or biological backgrounds, but both must possess computer
skills and an interest and basic understanding of molecular biology. We
expect all applicants to have a good publication record; this will be one of
the most important criteria for selecting candidates for interview.

Please apply via E-mail to Julian Gough ( including a
C.V. with publication list and cover letter. Formal details of the position
are available on request.

Dr. Julian Gough
Reader, University of Bristol
Department of Computer Science
Merchant Venturers Building
Woodland Road, Bristol, UK
Tel: +44 (0)117 3315221

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Published at 09-10-2009
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